Priapism: Trazodone Versus Nefazodone

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Letter to the Editor

Sir: The incidence of sexual dysfunction with antidepressant drugs varies from a low of 1.9% to a high of 91%.1 Such dysfunctions are believed to result from interactions with various neurotransmitter systems. One of the most dramatic and potentially disabling is priapism, which is a prolonged, dysfunctional penile erection that is painful and impairs sexual desire.

J Clin Psychiatry 1996;57(11):547-548 [letter]