Coadministration of Isoniazid and Antidepressant Drugs
J Clin Psychiatry 1996;57(11):550 [letter]
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Letter to the Editor
Sir: Isonicotinylhydrazide, also known as isoniazid, is a
well-known agent for treatment of mycobacterial infections. It
is also used for prevention of tuberculosis, given 300 mg/day
for a period of at least 6 months. In vivo studies, using
benzylamine as substrate, have demonstrated that isoniazid in
therapeutic doses inhibits plasma monoamine oxidase (MAO)
with no significant effect on platelet MAO.