Coadministration of Isoniazid and Antidepressant Drugs

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Letter to the Editor

Sir: Isonicotinylhydrazide, also known as isoniazid, is a well-known agent for treatment of mycobacterial infections. It is also used for prevention of tuberculosis, given 300 mg/day for a period of at least 6 months. In vivo studies, using benzylamine as substrate, have demonstrated that isoniazid in therapeutic doses inhibits plasma monoamine oxidase (MAO) with no significant effect on platelet MAO.

J Clin Psychiatry 1996;57(11):550 [letter]