Fluoxetine-Induced Akathisia Does Not Reappear After Switch to Paroxetine

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Letter to the Editor

Sir: The serotonin selective reuptake inhibitors (SSRIs), such as fluoxetine, sertraline, and paroxetine, have been repeatedly reported to produce akathisia that responded well to treatment with the ß-adrenergic antagonist propranolol, dose reduction, or both. We report two cases of patients with refractory major depression who suffered from severe fluoxetine-induced akathisia that disappeared completely after fluoxetine withdrawal and did not reappear after administration of an equivalent dose of paroxetine, another SSRI antidepressant.

J Clin Psychiatry 1996;57(12):593-594 [letter]