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Mandibular Dystonia Associated With the Combination of Sertraline and Metoclopramide

J Clin Psychiatry 1996;57(12):596 [letter]

Letter to the Editor

Sir: We report a case of mandibular dystonia that developed after sertraline, a serotonin reuptake inhibitor (SRI), was added to a chronic regimen of metoclopramide.

Case report. Ms. A, a 23-year-old white woman with no prior history of depression, presented to our inpatient crisis unit with a major depressive episode of 2 months’ duration. Her only significant physical illness was gastroesophageal reflux, which had been well controlled for the prior 6 months with metoclopramide 15 mg q.i.d.