Exercise-Induced Orgasms Associated With Fluoxetine Treatment of Depression

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Letter to the Editor

Sir: Paradoxically, fluoxetine has been reported both to delay or abolish orgasms1 and also to induce spontaneous orgasms. Fluoxetine-associated exercise-induced orgasms represent an additional orgasmic disturbance that, to my knowledge, has not previously been reported. This letter reports a woman whose fluoxetine treatment for depression was accompanied by the development of orgasms arising unintentionally during vigorous exercise. The co-occurrence of these exerciseinduced orgasms with the development of delayed orgasms during purposeful sexual activity may shed light on the relationship of serotonergic medications to sexual function.

J Clin Psychiatry 1996;57(12):596-597 [letter]