Cessation of Self-Mutilation in a Patient With Borderline Personality Disorder Treated With Naltrexone

View This PDF

NB: This article is only available as a PDF.

Letter to the Editor

Sir: Self-mutilation and self-injurious behavior may be due in part to dysregulation of endorphin neurotransmitter systems. Self-mutilation and dissociation occur frequently in patients with borderline personality disorder and associated histories of traumatic abuse and neglect, suggesting there may be an etiologic relationship between trauma, neglect, endorphin system dysfunction, and self-mutilation. This hypothesis is supported by the observation that some patients with borderline personality disorder have elevated pain thresholds, a phenomenon mediated in part by endorphin systems.

J Clin Psychiatry 1997;58(1):32-33 [letter]