SSRI Optimal Dose Remains at Issue

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Letter to the Editor

Sir: Drs. Gammon and Lane assert that Dr. Nemeroff erred when, in his review of drug treatment of depression, he said that most patients require more than 50 mg/day of sertraline, in distinction to other serotonin selective reuptake inhibitors, which require no more, usually, than the initial dosage: paroxetine 20 mg/day and fluoxetine 20 mg/day. They even accuse Dr. Nemeroff of bias because his paper came from a presentation supported by the makers of paroxetine. Dr. Nemeroff defended himself by referring to dose-response literature.

J Clin Psychiatry 1997;58(2):87-88 [letter]