SSRI Optimal Dose Remains at Issue
J Clin Psychiatry 1997;58(2):87-88 [letter]
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Letter to the Editor
Sir: Drs. Gammon and Lane assert that Dr. Nemeroff erred
when, in his review of drug treatment of depression, he said
that most patients require more than 50 mg/day of sertraline, in
distinction to other serotonin selective reuptake inhibitors,
which require no more, usually, than the initial dosage: paroxetine
20 mg/day and fluoxetine 20 mg/day. They even accuse Dr.
Nemeroff of bias because his paper came from a presentation
supported by the makers of paroxetine. Dr. Nemeroff defended
himself by referring to dose-response literature.