Mania Associated With Serotonin Selective Reuptake Inhibitors

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Letter to the Editor

Sir: Patients with bipolar affective disorder encounter an increased risk of mania during antidepressive therapy with tricyclic antidepressants (TCAs). Serotonin selective reuptake inhibitors (SSRIs) have been demonstrated to be effective antidepressants with a low incidence of side effects. While several cases of antidepressant-induced mania during therapy with the SSRIs fluvoxamine and fluoxetine have been published elsewhere, we present six cases of SSRI-induced mania during antidepressive therapy with two newer SSRIs, citalopram and paroxetine.

J Clin Psychiatry 1997;58(2):88-89 [letter]