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Sertraline-Induced Anorgasmia Treated With Intermittent Nefazodone

J Clin Psychiatry 1997;58(2):89 [letter]

Letter to the Editor

Sir: The trend of using serotonin selective reuptake inhibitors (SSRIs) as first-line therapy for depression has brought safe, effective, and well-tolerated therapy to countless patients. However, many men and women taking these drugs (fluoxetine, fluvoxamine, paroxetine, and sertraline) experience orgasmic dysfunction. Attempts to help these unfortunate patients with cyproheptadine, amantadine, yohimbine, and methylphenidate have had mixed success.