Bupropion for SSRI-Induced Fatigue

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Letter to the Editor

Sir: While depression, dysthymia, and panic disorder can often be effectively treated with the selective serotonin reuptake inhibitors (SSRIs), patients are sometimes left with treatmentemergent sedation or fatigue that can itself be quite disabling. Although Keck and McElroy3 postulated that, for fluoxetine, this may be related to an elevated norfluoxetine/fluoxetine ratio, personal experience has shown this fatigue to be present in some cases where the tested ratio was less than one.

J Clin Psychiatry 1997;58(4):174 [letter]