Pharmacologic Properties of Venlafaxine

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Letter to the Editor

Sir: Findling et al. (May 1996 issue) report on their study of venlafaxine in adult ADHD. Their rationale for the research was simply that venlafaxine is an antidepressant; the fact that the medication and its metabolite, O-desmethylvenlafaxine (ODV), are weak inhibitors of dopamine reuptake is not mentioned. Even in the brief paragraph on the pharmacology of venlafaxine, its dopaminergic property is not alluded to, although there is a general statement that, like tricyclic antidepressants, venlafaxine inhibits synaptic monoamine reuptake.

J Clin Psychiatry 1997;58(4):178 [letter]