Safety in Overdose of Mirtazapine: A Case Report

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Letter to the Editor

Sir: The new antidepressant mirtazapine (Remeron) has a unique mode of action, combining an increase of noradrenergic and 5-HT1A-mediated serotonergic neurotransmission with a specific blockade of 5-HT2 and 5-HT3-receptor subtypes. So far, a single case of overdose with mirtazapine has been reported since its introduction in The Netherlands in September 1994; I now report the second case.

J Clin Psychiatry 1997;58(6):271 [letter]