Lamotrigine Treatment of Refractory Bipolar Disorder

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Letter to the Editor

Sir: Lamotrigine represents a new class of anticonvulsant for the treatment of adult patients with refractory partial seizures. Lamotrigine is chemically unrelated to carbamazepine and phenytoin, but is thought to act at voltage-sensitive sodium channels to stabilize neuronal membranes and inhibit transmitter release, principally glutamate and aspartate, similar to the inhibition of neuronal activity produced by phenytoin and carbamazepine. Further, lamotrigine has been shown to possess efficacy similar to that of carbamazepine in control of onset of partial seizures and primary generalized tonic-clonic seizures.

J Clin Psychiatry 1997;58(6):271-273 [letter]