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Cost-Effectiveness of Divalproex Versus Lithium

J Clin Psychiatry 1997;58(8):363 [letter]

Letter to the Editor

Sir: We read with interest the recent application by Keck et al. of pharmacoeconomic analysis to the treatment of bipolar disorder. Their study suggested that divalproex was more costeffective in treating mixed and rapid cycling manic states, that lithium was more cost-effective in treating classic mania, and that divalproex was more cost-effective when mixed, rapid cycling, and classic mania were combined. Like Keck et al., we noted the sensitivity of the model to assumptions about the length of stay (LOS) for divalproex versus lithium.