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Oxybutynin and Intranasal Desmopressin for Clozapine-Induced Urinary Incontinence

J Clin Psychiatry 1997;58:404 [letters]

Letter to the Editor

Sir: In their report on the efficacy of ephedrine in the treatment of clozapine-induced urinary incontinence, Fuller et al. report that in their clinical experience with hospitalized psychiatric patients oxybutynin was ineffective in the management of this side effect. We have found both oxybutynin and intranasal desmopressin to be effective in the treatment of outpatients with clozapine-induced urinary incontinence.

As part of the Continuing Care Division, a community-based program of services for the severely and persistently mentally ill, the Clozapine Treatment Program provides case management and medical services to 71 patients with treatmentresistant psychosis managed with clozapine.