Oxcarbazepine for Panic Disorder Occurring After Two Grand Mal Seizures: A Case Report

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Letter to the Editor

Sir: Recently, pathophysiologic relations between panic disorder and epilepsy, at least in a subgroup of patients, have been hypothesized, and thus the rational use of anticonvulsants in panic disorder has been proposed. Several preliminary non-placebo- controlled studies used carbamazepine successfully in panic disorder, even though one non-placebo-controlled study found carbamazepine ineffective. Oxcarbazepine (Trileptal) is a new anticonvulsant substance with a chemical structure related to that of carbamazepine but with quite different metabolic pathways and active metabolites. Oxcarbazepine has not been studied in panic disorder yet. We present a patient who developed panic disorder after suffering from two grand mal seizures and in whom both conditions were relieved by oxcarbazepine.

J Clin Psychiatry 1997;58(9):404-405 [letter]