A Novel Placebo Lead-In Behavior Strategy for Sertraline Dosing in a Depressed Patient Highly Sensitive to Medication Side Effects

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Letter to the Editor

Sir: Medication compliance in mood disorders is a complex process that challenges patients and clinicians.

Case report. I report the successful treatment of a 49- year-old woman with a 20-year history of major depressive disorder, recurrent type without full interepisode recovery, who had previously discontinued several trials of antidepressant medications due to side effects. Earlier treatments with psychoanalysis, group psychotherapy, and individual supportive psychotherapy failed to relieve symptoms of depression.

J Clin Psychiatry 1997;58(9):405-406 [letter]