Academic Highlights: The Pharmacologic Rationale for the Clinical Use of Antidepressants
J Clin Psychiatry 1997;58:501-508
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Mirtazapine is the latest in a line of
drugs that have recently been introduced
for the treatment of depression.
It is now available worldwide and has
been used in more than 170,000 patients
(May 1997). The novelty of this
drug over other antidepressants lies
particularly in its unique mechanism
Mirtazapine inhibits neither the
reuptake of norepinephrine (NE), serotonin
(5-HT), or dopamine (DA) nor
the activity of monoamine oxidase,
thereby clearly being distinguished
from the tricyclic antidepressants
(TCAs), newer reuptake inhibitors of
either serotonin and/or norepinephrine
(SSRI/SNRI), and the monoamine oxidase