Effects of Olanzapine on Polydipsia and Intermittent Hyponatremia

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Letter to the Editor

Sir: The syndrome of polydipsia and intermittent hyponatremia is a well-documented problem affecting psychotic patients. Recent studies, however, indicate the treatment with atypical antipsychotic agents is associated with decreased water consumption and normalization of serum sodium levels. Olanzapine recently became available in the United States and is characterized as a selective monoaminergic antagonist with high affinity binding to serotonin, dopamine, muscarinic, histamine, and adrenergic receptors (package insert, 1996).

J Clin Psychiatry 1997;58(12):549 [letter]