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A Possible Pharmacokinetic Interaction Between Fluoxetine and Acetylsalicylic Acid

J Clin Psychiatry 1997;58(12):549-550 [letter]

Letter to the Editor

Sir: In rare instances, fluoxetine has been shown to cause skin rashes. During fluoxetine treatment, our patient experienced hives that resolved after antidepressant discontinuation, only to recur when the patient took acetylsalicylic acid (ASA, aspirin) for pain relief.

Case report. A 44-year-old healthy, physically active, white man developed major depressive disorder after a period of extreme stress.