Elevated Plasma Clozapine Concentrations After Phenobarbital Discontinuation
J Clin Psychiatry 1998;59:131-133 [letter]
© Copyright 2014 Physicians Postgraduate Press, Inc.
Access to this article is available to valid users
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Register: If you do not have one already, register for a free account.
Sir: Clozapine, an atypical antipsychotic drug, is used mainly for treatment-resistant schizophrenia. Its metabolism is quite complex and involves a number of human cytochrome P450 enzymes and flavin-containing monooxygenases. Among them, cytochrome P450 1A2 (CYP1A2) appears to be the main enzyme responsible for the metabolism of clozapine. However, other isozymes, including CYP3A3/4, might also partially mediate clozapine’s disposition.