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Bipolar Depression Associated With Fenfluramine and Phentermine

J Clin Psychiatry 1998;59(7):383-384 [letter]

Sir: Fenfluramine and phentermine have often been used in combination for the treatment of obesity. Although the Physicians’ Desk Reference lists depression as a potential adverse effect of fenfluramine, it is not contraindicated in the treatment of patients with comorbid mood disorders. We present the case of a woman with a history of bipolar disorder who developed a major depressive episode following administration of fenfluramine and phentermine.