Bipolar Depression Associated With Fenfluramine and Phentermine
J Clin Psychiatry 1998;59(7):383-384 [letter]
© Copyright 2016 Physicians Postgraduate Press, Inc.
Sir: Fenfluramine and phentermine have often been used in combination for the treatment of obesity. Although the Physicians’ Desk Reference lists depression as a potential adverse effect of fenfluramine, it is not contraindicated in the treatment of patients with comorbid mood disorders. We present the case of a woman with a history of bipolar disorder who developed a major depressive episode following administration of fenfluramine and phentermine.