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Safety in Overdose of Quetiapine: A Case Report

J Clin Psychiatry 1998;59:433-433 [letter]

Sir: Quetiapine (Seroquel) is a new atypical antipsychotic drug belonging to a new chemical class, the dibenzothiazepine derivatives. It is a serotonin and dopamine receptor antagonist, which also has antagonistic activity at α-adrenergic and histamine receptor sites. A MEDLINE review of the literature yielded no prior published reports of quetiapine overdosage. Therefore, we report the case of a patient who intentionally ingested a large quantity of quetiapine.