Treatment of Venlafaxine Discontinuation Symptoms With Ondansetron
J Clin Psychiatry 1998;59(11):621-622 [letter]
© Copyright 2015 Physicians Postgraduate Press, Inc.
Access to this article is available to valid users
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Register: If you do not have one already, register for a free account.
Sir: Discontinuation symptoms that emerge during sudden or gradual discontinuation of serotonin-norepinephrine reuptake inhibitors (SNRIs), such as venlafaxine, have been reported. The short half-life of 5 hours for venlafaxine renders patients vulnerable to nausea, headache, gastric upset, diarrhea, myalgia, and fatigue upon lowering of the dosage. The manufacturer recommends a gradual discontinuation of venlafaxine to avoid the emergence of such symptoms.