Can Long-Term Antidepressant Use Be Depressogenic?
J Clin Psychiatry 1999;60(4):263 [letter]
© Copyright 2017 Physicians Postgraduate Press, Inc.
Letter to the Editor
Sir: We appreciated the thoughtful review on the loss of antidepressant efficacy by Byrne and Rothschild. We would like to put forward another possible explanation for the observation: long-term antidepressant use may be depressogenic. While this idea seems counterintuitive, there are reasons to seriously consider it.