The article you requested is

Lack of Desipramine Toxicity With Citalopram

J Clin Psychiatry 2000;61(2):144 [letter]

Letter to the Editor

Sir: Selective serotonin reuptake inhibitors (SSRIs) are known to inhibit specific human hepatic cytochrome P450 (CYP) isoenzymes, which are critical in the metabolism of most medications. Paroxetine is thought to possess highly potent inhibiting properties for the CYP2D6 isoenzyme. CYP2D6 is the major enzyme involved in catabolism of many commonly used agents, including neuroleptics, antidepressants, Type IC antiarrhythmics, codeine, ß-blockers, and dextromethorphan.