Lack of Desipramine Toxicity With Citalopram
J Clin Psychiatry 2000;61:144 [letter]
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Letter to the Editor
Sir: Selective serotonin reuptake inhibitors (SSRIs) are
known to inhibit specific human hepatic cytochrome P450
(CYP) isoenzymes, which are critical in the metabolism of most
medications. Paroxetine is thought to possess highly potent
inhibiting properties for the CYP2D6 isoenzyme. CYP2D6 is
the major enzyme involved in catabolism of many commonly
used agents, including neuroleptics, antidepressants, Type IC
antiarrhythmics, codeine, ß-blockers, and dextromethorphan.