Treatment of Kleine-Levin Syndrome: Melatonin on the Starting Block
J Clin Psychiatry 2000;61(3):215 [letter]
© Copyright 2015 Physicians Postgraduate Press, Inc.
Letter to the Editor
Sir: Kleine-Levin syndrome (KLS) is complex and rare,
primarily affects adolescent males, and is characterized by recurrent
attacks of hypersomnia, excessive eating, and striking
behavioral and psychiatric symptoms. It has been hypothesized
that KLS is related to bipolar affective spectrum disorders.
Exogenous melatonin administration does not seem to improve
patients with rapid-cycling bipolar disorder. This treatment,
however, has not yet been tested in KLS. We report a case of a
man with persistent KLS symptoms that were alleviated after
treatment with exogenous melatonin.