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Treatment of Kleine-Levin Syndrome: Melatonin on the Starting Block

J Clin Psychiatry 2000;61:215 [letter]

Letter to the Editor

Sir: Kleine-Levin syndrome (KLS) is complex and rare, primarily affects adolescent males, and is characterized by recurrent attacks of hypersomnia, excessive eating, and striking behavioral and psychiatric symptoms. It has been hypothesized that KLS is related to bipolar affective spectrum disorders. Exogenous melatonin administration does not seem to improve patients with rapid-cycling bipolar disorder. This treatment, however, has not yet been tested in KLS. We report a case of a man with persistent KLS symptoms that were alleviated after treatment with exogenous melatonin.