SIADH With Multiple Antidepressants in a Geriatric Patient

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Letter to the Editor

Sir: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a known side effect of psychopharmacotherapy, having been reported with nearly all psychotropic drugs. The mechanism of drug-induced SIADH is thought to be mediated serotonergically, but the mechanism is not known for certain at this time. It is often difficult to predict which patients will develop this complication, although certain risk factors are known, such as age = 65 years, concomitant diuretic use, and smoking.

J Clin Psychiatry 2000;61(6):448-449 [letter]