Bupropion-Tranylcypromine Combination for Treatment-Refractory Depression

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Letter to the Editor

Sir: We report the safe and successful use of combined bupropion and tranylcypromine in a case of treatment-refractory depression.

Case report. Ms. A, a 27-year-old woman with chronic major depression (DSM-III-R criteria), was treated in 1990 at age 17 with imipramine up to 150 mg/day. In March 1994, after a suicide attempt by imipramine overdose, paroxetine, 20 mg/day, replaced imipramine. On paroxetine, 30 mg/day, and amitriptyline, 50 mg q.h.s., she experienced only mild improvement at 6 months.

J Clin Psychiatry 2000;61(6):450-451 [letter]