Patient Compliance to a New Enteric-Coated Weekly Formulation of Fluoxetine During Continuation Treatment of Major Depressive Disorder
J Clin Psychiatry 2000;61:928-932
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: A new formulation of enteric-coated
fluoxetine given once weekly could be a useful option for the
long-term treatment of depression, but compliance to once-weekly
fluoxetine treatment has not been assessed.
Method: Patients were adults from the United
Kingdom who had responded to fluoxetine treatment for a current
episode of depression (DSM-IV criteria). In the baseline
assessment phase, all patients (N = 117) were continued on 20 mg
of open-label fluoxetine once daily for 4 weeks. In the follow-up
phase, patients (N = 109) were randomly assigned to once-weekly
or once-daily fluoxetine for 3 months. Patient compliance was
monitored by electronic devices during both phases of the study.
Results: Compliance to once-weekly fluoxetine
treatment was higher than compliance to once-daily fluoxetine
(85.9% vs. 79.4%, respectively).
Conclusion: Once-weekly fluoxetine treatment
allows for new flexibility for both the clinician and the
patient, and this study alleviates the concern that patients will
forget weekly doses.