Olanzapine Treatment of Female Borderline Personality Disorder Patients: A Double-Blind, Placebo-Controlled Pilot Study
J Clin Psychiatry 2001;62:849-854
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: The intent of this study was to
compare the efficacy and safety of olanzapine versus placebo in
the treatment of women meeting criteria for borderline
personality disorder (BPD).
Method: We conducted a double-blind,
placebo-controlled study of olanzapine in 28 female subjects
meeting Revised Diagnostic Interview for Borderlines and DSM-IV
criteria for BPD. The subjects were randomly assigned to
olanzapine or placebo in a 2:1 manner. Treatment duration was 6
months. Primary outcome measures were self-reported changes on
anxiety, depression, paranoia, anger/hostility, and interpersonal
sensitivity scales of the Symptom Checklist-90.
Results: Nineteen subjects were randomly
assigned to olanzapine; 9, to placebo. When random effects
regression modeling of panel data was used, controlling for
baseline level of severity, olanzapine was associated with a
significantly (p < .05) greater rate of improvement over time
than placebo in all of the symptom areas studied except
depression. Weight gain was modest in the olanzapine-treated
group but was significantly higher than in those treated with
placebo (p < .02). In addition, no serious movement disorders
Conclusion: Olanzapine appears to be a safe and
effective agent in the treatment of women with criteria-defined
BPD, significantly affecting all 4 core areas of borderline
psychopathology (i.e., affect, cognition, impulsivity, and