Clinical Experience With Insulin Resistance, Diabetic Ketoacidosis, and Type 2 Diabetes Mellitus in Patients Treated With Atypical Antipsychotic Agents

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Numerous reports have associated atypical antipsychotic agents with hyperglycemia, diabetes mellitus, and diabetic ketoacidosis. Although the mechanisms are poorly understood, clinical experience suggests that these adverse effects are major areas of concern and require attention by the psychiatric team and primary care clinicians. This article discusses my clinical experience with glucose metabolism impairment related to treatment with antipsychotic medications.

J Clin Psychiatry 2001;62(suppl 27):10-14