Switch to Mania After Slow rTMS of the Right Prefrontal Cortex

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Letter to the Editor

Sir: Recent evidence indicates that slow repetitive transcranial magnetic stimulation (rTMS) of the right dorsolateral prefrontal cortex (DLPFC) exerts antidepressant effects. Here, we report on 2 patients suffering from a therapy-resistant major depressive episode who had given their written informed consent to participate in a controlled rTMS trial. Both patients underwent 1-Hz rTMS of the right DLPFC and switched from depression to a manic state.

J Clin Psychiatry 2002;63(3):249