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Oxcarbazepine-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone

J Clin Psychiatry 2002;63:742 [letter]

Letter to the Editor

Sir: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a relatively rare syndrome that occurs in various circumstances such as central nervous system diseases, cancers, and infections. SIADH is also reported to be associated with use of some psychotropic drugs, e.g., carbamazepine, neuroleptics, tricyclic antidepressants, and, more recently, selective serotonin reuptake inhibitors. Common symptoms of SIADH include weakness, lethargy, headache, anorexia, and weight gain. These symptoms may be followed by confusion, convulsions, coma, and death. The early symptoms are vague and nonspecific and may mimic the symptoms of the psychiatric disorder itself.