High Degree of Tolerability for Monotherapy With High Doses of Quetiapine: A Case Report

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Letter to the Editor

Sir: Quetiapine is a relatively new third-generation antipsychotic with a labeled dose range of 400 to 800 mg/day. Quetiapine has demonstrated efficacy in the management of patients with a history of partial response to conventional antipsychotics. We report the case of a schizophrenic woman who achieved full clinical remission without significant side effects with a high dose of quetiapine (1600 mg/day). To our knowledge, evidence from daily clinical practice or controlled clinical trials has never been published on high doses of this new antipsychotic.

J Clin Psychiatry 2002;63(11):1048-1049