Introduction. Quetiapine: A 5-Year Update

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The treatment of schizophrenia changed in the 1950s with the discovery of conventional antipsychotics, such as chlorpromazine and haloperidol. In the ensuing decade, it became apparent that many patients would have an incomplete or partial response, with clinically significant positive symptoms remaining despite optimal dosing. It also became clear that typical antipsychotics were not effective against the most disabling aspects of schizophrenia, the negative symptoms and cognitive impairments.​

J Clin Psychiatry 2002;63(suppl 13):3-4