Anxiety Associated With Comorbid Depression
J Clin Psychiatry 2002;63(suppl 14):22-26
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Historically, the clinical term for mixed depression and anxiety was anxious depression. With the
publication of DSM-III-R, 2 categories were established for the purpose of classifying disorders that
involve both anxiety and depression, and that classification system is currently used in DSM-IV as
well. These more specific diagnostic criteria have given us a much better understanding of the anxiety
spectrum, but have created a need for a better understanding of the place of benzodiazepines in clearly
defined indications on the anxiety spectrum. In spite of warnings about side effects, misuse, and dependence,
benzodiazepines are frequently prescribed as adjunctive therapy to antidepressants for comorbid
anxiety and depression. This article presents data on the prevalence, course, and outcome of
comorbid anxiety and depression. It also compares efficacy data from trials of benzodiazepines used
alone and in combination with antidepressants for the treatment of anxiety disorders comorbid with