Lack of Association Between Plasma Apolipoprotein E and Suicide Attempts

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Sir: Low cholesterol may be associated with increased suicide attempt risk.1,2 Apolipoprotein E is a plasma protein that serves as a ligand for the low-density lipoprotein receptors and, through its interaction with these receptors, participates in cholesterol transport.3 No published studies have explored the association between plasma apolipoprotein E and suicide. This study compared plasma apolipoprotein E levels in 298 suicide attempters seen in the emergency room and 258 controls.

J Clin Psychiatry 2004;65(4):580[letter]