Transient Hyperproinsulinemia DuringTreatment With Clozapine and Amisulpride

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Sir: Impaired glucose metabolism may occur during treatment with second-generation antipsychotics, predominantly clozapine, olanzapine, and quetiapine.1,2 The mechanisms involved in this metabolic side effect of antipsychotic therapy seem to be complex and are a point of ongoing discussion, especially as they relate to the use of antipsychotic combination therapy in treatment-resistant patients.3

J Clin Psychiatry 2004;65(6):878-879