Venlafaxine XR and Chronic Pelvic Pain Syndrome

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Sir: Venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor (SNRI), has been shown to have analgesic effects in neuropathic1–3 and postsurgical pain4 and in pain and uncomfortable physical symptoms associated with premenstrual dysphoric disorder.5 This agent has also been reported to both prevent and resolve hyperalgesia in rats with experimentally produced painful neuropathic lesions.6

J Clin Psychiatry 2004;65(6):880-881