Respiratory Infections Rather Than Antibiotics May Increase Clozapine Levels: A Critical Review of the Literature
J Clin Psychiatry 2004;65(8):1144-1145 [letter]
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Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.
Sir: Approximately 70% of clozapine metabolism is explained by the cytochrome P450 1A2 (CYP1A2).1 The CYP1A2 can be inhibited by respiratory infections. Decreased theophylline (a CYP1A2 substrate) clearance during upper respiratory infections has been described in asthmatic children2,3 and in adults with chronic bronchitis.4