The article you requested is
Academic Highlights: Enhancing Treatment Response in Depression. [CME]
Philip T. Ninan, MD; Maurizio Fava, MD; and Kerry J. Ressler, MD, PhD
J Clin Psychiatry 2004;65(9):1269-1280
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Article Abstract
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Kerry J. Ressler, MD, PhD, opened with the statement that the symptoms of major depressive disorder can be viewed as a result of brain circuit dysfunction. Three classes of molecules involved in depressive symptoms include the monoamines, which regulate broad functioning of neural circuits; neuropeptides, which mediate behavior-specific components of neural circuits; and neurotrophins, which allow for plasticity of the brain and maintenance of neural circuits.