Possible Increased Efficacy of Low-Dose Clozapine When Combined With Aripiprazole
J Clin Psychiatry 2004;65:1284-1285 [letter]
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.
Sir: Clozapine has been shown to be superior to typical antipsychotics in treatment-refractory schizophrenic patients. However, patients are sometimes unable to tolerate full therapeutic doses of clozapine because of significant adverse central nervous system and gastrointestinal effects at high doses. Aripiprazole is a new antipsychotic with a novel mechanism of action.