A Case of Venous Thromboembolism Probably Associated With Hyperprolactinemia After the Addition of Olanzapine to Typical Antipsychotics

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Sir: Whereas there are numerous reports of venous thromboembolic complications in patients treated with typical antipsychotics, especially chlorpromazine, only a few cases of thromboembolisms associated with atypical antipsychotics such as olanzapine and quetiapine are documented.1 We report a case in which augmentation with olanzapine to alleviate chronic psychotic symptoms accompanied by intermittent manic episodes led to pulmonary thromboembolism. Since analysis of the physical condition of the patient revealed no well-known risk factor for thromboembolism, we speculate that hyperprolactinemia induced by olanzapine augmentation may be, at least in part, involved in the pathogenesis of thromboembolism.

J Clin Psychiatry 2004;65(11):1576-1577