Bupropion for Patients With Obsessive-Compulsive Disorder: An Open-Label, Fixed-Dose Study
J Clin Psychiatry 2005;66(2):228-230
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Objective: In the present study, we examined the
efficacy of bupropion for patients with obsessive-compulsive
Method: Twelve patients with OCD according to
DSM-IV criteria were included in an open trial with bupropion,
maximum dosage 300 mg per day, during 8 weeks. The primary
efficacy parameter was the Yale-Brown Obsessive Compulsive Scale
(YBOCS). A responder was defined by a reduction in score on the
YBOCS of >= 25%. Data were collected from February 2003 to
Results: An intent-to-treat analysis using the
last observation carried forward demonstrated that bupropion had
no mean effect on OCD symptoms (mean YBOCS decrease was 1.1 ±
9.6). Four patients improved, with a mean decrease on the YBOCS
of 31%, and 2 of them met responder rate criteria. Eight patients
experienced an exacerbation of OCD symptoms, with a mean increase
on the YBOCS of 21%.
Conclusion: Bupropion is not an effective
treatment for OCD, but the bimodal distribution of the effect
supports the notion that dopamine might be involved in the
pathophysiology of OCD.