Historical Comments on Tardive Dyskinesia: A Neurologist's Perspective
J Clin Psychiatry 2005;66(2):260-264
© Copyright 2014 Physicians Postgraduate Press, Inc.
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This article was undertaken to review the history of
professional awareness of tardive dyskinesia (TD) and to address
reasons for the delay in such recognition. The literature was
reviewed, and selections are included to highlight some of the
major issues. Personal recollections are deliberately emphasized
since they may reflect the phenomenon of personal discovery
familiar to others and the now widespread professional awareness
of TD. TD is indeed well recognized by psychiatrists and
neurologists, and most general practitioners are also aware that
the syndrome exists. Physicians were once unfamiliar with the
concept of a drug reaction that was so long delayed as is
possible with TD, nor did they know that a drug side effect could
present in this manner. The historical delay in initial
recognition of TD, and the reason for such delay, remain of
interest. The lack of a perfect therapy and the uncertainty
regarding the precise pathophysiologic basis of TD remain as
challenges. Most psychiatrists, and many neurologists, probably
have vivid memories of specific patients with TD. This author, a
neurologist, was blessed to work with George Crane and other
investigators in the early days of TD and was witness to some of
the original uncertainty regarding what seemed to be a new
phenomenon. TD has reshaped our concepts of disease and our
awareness that diseases can originate from deleterious late
effects of beneficial agents.