Efficacy of Quetiapine in Generalized Social Anxiety Disorder: Results From an Open-Label Study

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Sir: The generalized form of social anxiety disorder is a highly prevalent psychiatric condition that causes persistent functional impairment.1 Although selective serotonin reuptake inhibitors (SSRIs) have become the first-line treatment for social anxiety disorder,2 these drugs do not always give adequate symptom relief, and side effects like initial increase of anxiety, gastrointestinal complaints, and sexual dysfunction can complicate their long-term use. Animal models have shown that atypical antipsychotics also possess anxiolytic properties.3–5

J Clin Psychiatry 2005;66(4):540-542