Low-Dose Risperidone and Quetiapine as Monotherapy for Comorbid Anxiety and Depression

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Sir: Up to 80% of patients with generalized anxiety disorder (GAD) suffer from a comorbid mood disorder.1 Atypical antipsychotics are frequently prescribed as off-label adjunctive treatment for GAD and major depressive disorder (MDD); however, no studies have demonstrated the effectiveness of these drugs as monotherapy.2,3 Here, we present a case series describing the use of risperidone and quetiapine as monotherapy for GAD and MDD.​​

J Clin Psychiatry 2005;66(4):544