A Placebo-Controlled, Randomized, Double-Blind Study of Adjunctive Bupropion Sustained Release in the Treatment of SSRI-Induced Sexual Dysfunction
J Clin Psychiatry 2005;66(7):844-848
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: Sexual side effects are among the
common reasons patients discontinue selective serotonin reuptake
inhibitors (SSRIs). While many antidotes have been proposed, few
have been subjected to double-blind trials. Some evidence has
suggested that bupropion may be an effective antidote for
SSRI-induced sexual dysfunction. In this double-blind trial, the
efficacy of a standard dose of bupropion sustained release (SR)
is evaluated in the treatment of SSRI-induced sexual dysfunction.
Method: Patients with a history of SSRI-induced
sexual side effects were randomly assigned to adjunctive
treatment with either bupropion SR 150 mg daily or placebo for 6
weeks. Assessments of sexual function and interest included the
Arizona Sexual Experiences Scale (ASEX), Brief Index of Sexual
Functioning, and a 10-point visual analogue scale. Efficacy was
defined as a 50% improvement on the ASEX at the end of 6 weeks.
Data were collected from January 1999 to March 2001.
Results: Forty-one patients entered the study
and completed the 6-week trial. No significant differences were
seen between placebo and bupropion SR on the ASEX or on any
measure of sexual functioning at the end of the trial.
Conclusion: A fixed dose of 150 mg/day of
bupropion SR taken in the morning does not appear to be effective
in the treatment of SSRI-induced sexual dysfunction. Additional
trials will be required to define what role, if any, bupropion
might have in the treatment of SSRI-induced sexual side effects.