Possible Bipolar Nature of Irritability in Major Depressive Disorder
J Clin Psychiatry 2005;66(8):1072-1072 [letter]
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Perlis et al.1
found that irritability was present in 40% of
outpatients with major depressive disorder (MDD). The finding
which lists irritability not only as a core
symptom of mania and hypomania, but also as a common
symptom of MDD. Kraepelin3
classified irritability as a manic
(excitement) symptom. The bipolar nature of irritability in
MDD can have an important impact on treatment of MDD.
Although a study4
on MDD with irritability showed that fluoxetine
was effective in reducing irritability, clinical observations
suggest adding mood-stabilizing agents to antidepressants
in MDD with irritability because antidepressants alone may